PTEN
phosphatase and tensin homolog
Synonyms:
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1
Species:
Human PTEN (5728), Mouse Pten (19211), Rat Pten (50557), fruit fly Pten (43991), domestic cat PTEN (101091813), dog PTEN (403832), chicken PTEN (423675), cow PTEN (540786), sheep PTEN (101119351), domestic guinea pig Pten (100723659)
UniProtKB ID:
Gene ID:
- Human(5728) Summary: This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq, Jul 2008]
- Mouse(19211) phosphatase and tensin homolog
- Rat(50557) phosphatase and tensin homolog
- fruit fly(43991) CG5671 gene product from transcript CG5671-RB
- domestic cat(101091813) phosphatase and tensin homolog
- dog(403832) phosphatase and tensin homolog
- chicken(423675) phosphatase and tensin homolog
- cow(540786) phosphatase and tensin homolog
- sheep(101119351) phosphatase and tensin homolog
- domestic guinea pig(100723659) phosphatase and tensin homolog
- naked mole-rat(101714930) phosphatase and tensin homolog
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-PTEN (Ser370) Antibody, Upstate®, from rabbit,
Species Reactivity
mouse
Application
western blot
Anti-PTEN Antibody, clone 6H2.1, clone 6H2.1, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-PTEN Antibody, CT, clone A2b1, clone A2b1, Chemicon®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot