PRKAR2B
protein kinase, cAMP-dependent, regulatory, type II, beta
Synonyms:
PRKAR2, RII-BETA
Species:
Human PRKAR2B (5577), Mouse Prkar2b (19088), Rat Prkar2b (24679), chicken PRKAR2B (769420), domestic cat PRKAR2B (101081127), dog PRKAR2B (475887), domestic guinea pig Prkar2b (100719506), naked mole-rat Prkar2b (101706694), cow PRKAR2B (282463), sheep PRKAR2B (100500720)
UniProtKB ID:
Gene ID:
- Human(5577) Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]
- Mouse(19088) protein kinase, cAMP dependent regulatory, type II beta
- Rat(24679) protein kinase, cAMP dependent regulatory, type II beta
- chicken(769420) protein kinase, cAMP-dependent, regulatory, type II, beta
- domestic cat(101081127) protein kinase, cAMP-dependent, regulatory, type II, beta
- dog(475887) protein kinase, cAMP-dependent, regulatory, type II, beta
- domestic guinea pig(100719506) protein kinase, cAMP-dependent, regulatory, type II, beta
- naked mole-rat(101706694) protein kinase, cAMP-dependent, regulatory, type II, beta
- cow(282463) protein kinase, cAMP-dependent, regulatory, type II, beta
- sheep(100500720) protein kinase, cAMP-dependent, regulatory, type II, beta
- sheep(101106003) protein kinase, cAMP-dependent, regulatory, type II, beta
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Small Molecule - Inhibitor
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