PLOD2
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
Synonyms:
LH2, TLH
Species:
Human PLOD2 (5352), Mouse Plod2 (26432), Rat Plod2 (300901), Zebrafish plod2 (100036767), Horse PLOD2 (100061030), chicken PLOD2 (424882), dog PLOD2 (485702), domestic cat PLOD2 (101085741), domestic guinea pig Plod2 (100735218), naked mole-rat Plod2 (101708679) ...More
UniProtKB ID:
Gene ID:
- Human(5352) Summary: The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(26432) procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
- Rat(300901) procollagen lysine, 2-oxoglutarate 5-dioxygenase 2
- Zebrafish(100036767) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
- Horse(100061030) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
- chicken(424882) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
- dog(485702) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
- domestic cat(101085741) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
- domestic guinea pig(100735218) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
- naked mole-rat(101708679) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
- cow(533642) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
- sheep(101103613) procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
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