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PDE5A

phosphodiesterase 5A, cGMP-specific

Synonyms:

CGB-PDE, CN5A, PDE5

Species:

Human PDE5A (8654), Mouse Pde5a (242202), Rat Pde5a (171115), domestic guinea pig Pde5a (100527958), naked mole-rat Pde5a (101696421), Domestic Rabbit PDE5A (100354625), cow PDE5A (785098), cow PDE5A (281972), sheep PDE5A (100294560), sheep PDE5A (101109357) ...More

UniProtKB ID:

O76074, A0AV69, A8K2C4, O75026, O75887, Q86UI0, Q86V66, Q9Y6Z6

Gene ID:

Human(8654) Summary: This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Mouse(242202) phosphodiesterase 5A, cGMP-specific
Rat(171115) phosphodiesterase 5A, cGMP-specific
domestic guinea pig(100527958) phosphodiesterase 5A, cGMP-specific
naked mole-rat(101696421) phosphodiesterase 5A, cGMP-specific
Domestic Rabbit(100354625) phosphodiesterase 5A, cGMP-specific
cow(785098) phosphodiesterase 5A, cGMP-specific
cow(281972) phosphodiesterase 5A, cGMP-specific
sheep(100294560) phosphodiesterase 5A, cGMP-specific
sheep(101109357) phosphodiesterase 5A, cGMP-specific
chicken(422677) phosphodiesterase 5A, cGMP-specific
dog(403825) phosphodiesterase 5A, cGMP-specific
Horse(100072395) phosphodiesterase 5A, cGMP-specific
domestic cat(100533976) phosphodiesterase 5A, cGMP-specific

Products (9)
Peer Reviewed Papers (62)

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Small Molecule - Inhibitor

Product Number

Description

Species

Sildenafil for peak identification, European Pharmacopoeia (EP) Reference Standard,

Species

human

Sildenafil citrate, United States Pharmacopeia (USP) Reference Standard,

Species

human

Sildenafil Citrate, Pharmaceutical Secondary Standard; Certified Reference Material,

Species

human

Sildenafil citrate, European Pharmacopoeia (EP) Reference Standard,

Species

human

Dipyridamole for peak identification, European Pharmacopoeia (EP) Reference Standard,

Species

human