PAK7
p21 protein (Cdc42/Rac)-activated kinase 7
Synonyms:
PAK5
Species:
Human PAK7 (57144), Mouse Pak7 (241656), Rat Pak7 (311450), Zebrafish pak7 (405898), dog PAK7 (485772), chicken PAK7 (416734), Horse PAK7 (100051415), cow PAK7 (513432), domestic cat PAK7 (101091011), domestic guinea pig Pak7 (100731594) ...More
UniProtKB ID:
Gene ID:
- Human(57144) Summary: The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
- Mouse(241656) p21 protein (Cdc42/Rac)-activated kinase 7
- Rat(311450) p21 protein (Cdc42/Rac)-activated kinase 7
- Zebrafish(405898) p21(CDKN1A)-activated kinase 7
- dog(485772) p21 protein (Cdc42/Rac)-activated kinase 7
- chicken(416734) p21 protein (Cdc42/Rac)-activated kinase 7
- Horse(100051415) p21 protein (Cdc42/Rac)-activated kinase 7
- cow(513432) p21 protein (Cdc42/Rac)-activated kinase 7
- domestic cat(101091011) p21 protein (Cdc42/Rac)-activated kinase 7
- domestic guinea pig(100731594) p21 protein (Cdc42/Rac)-activated kinase 7
- naked mole-rat(101697197) p21 protein (Cdc42/Rac)-activated kinase 7
- sheep(101107882) p21 protein (Cdc42/Rac)-activated kinase 7
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