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Merck

PADI2

peptidyl arginine deiminase, type II

Synonyms:
PAD-H19, PAD2, PDI2
Species:
Human PADI2 (11240), Mouse Padi2 (18600), Rat Padi2 (29511), Zebrafish padi2 (386792), cow PADI2 (617851), Horse PADI2 (100050025), domestic cat PADI2 (101085301), chicken PADI2 (428172), dog PADI2 (487414), naked mole-rat Padi2 (101721485) ...More
UniProtKB ID:
Q9Y2J8, Q9UPN2
Gene ID:
  • Human(11240) Summary: This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
  • Mouse(18600) peptidyl arginine deiminase, type II
  • Rat(29511) peptidyl arginine deiminase, type II
  • Zebrafish(386792) peptidyl arginine deiminase, type II
  • cow(617851) peptidyl arginine deiminase, type II
  • Horse(100050025) peptidyl arginine deiminase, type II
  • domestic cat(101085301) peptidyl arginine deiminase, type II
  • chicken(428172) peptidyl arginine deiminase, type II
  • dog(487414) peptidyl arginine deiminase, type II
  • naked mole-rat(101721485) peptidyl arginine deiminase, type II
  • domestic guinea pig(100728531) peptidyl arginine deiminase, type II
  • sheep(101108464) peptidyl arginine deiminase, type II

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