NDUFS2
NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
Synonyms:
CI-49
Species:
Human NDUFS2 (4720), Mouse Ndufs2 (226646), Rat Ndufs2 (289218), domestic guinea pig Ndufs2 (100713270), naked mole-rat Ndufs2 (101701670), sheep NDUFS2 (101104108), Zebrafish ndufs2 (553672), chicken NDUFS2 (100857596), dog NDUFS2 (478981), cow NDUFS2 (327697)
UniProtKB ID:
Gene ID:
- Human(4720) Summary: The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
- Mouse(226646) NADH dehydrogenase (ubiquinone) Fe-S protein 2
- Rat(289218) NADH dehydrogenase (ubiquinone) Fe-S protein 2
- domestic guinea pig(100713270) NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
- naked mole-rat(101701670) NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
- sheep(101104108) NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
- Zebrafish(553672) NADH dehydrogenase (ubiquinone) Fe-S protein 2
- chicken(100857596) NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
- dog(478981) NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
- cow(327697) NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
- domestic cat(101088298) NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
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Small Molecule - Inhibitor
Product Number
Description
Species
Metformin hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human