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Merck

NANS

N-acetylneuraminic acid synthase

Synonyms:
SAS
Species:
Human NANS (54187), Mouse Nans (94181), Rat Nans (298071), sheep NANS (101104048), domestic guinea pig Nans (100716456), naked mole-rat Nans (101721582), Domestic Rabbit NANS (100356934), Zebrafish nans (322780), chicken NANS (427283), domestic cat NANS (101092303) ...More
UniProtKB ID:
Q9NR45, B2RE98, Q8WUV9, Q9BWS6, Q9NVD4
Gene ID:
  • Human(54187) Summary: This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]
  • Mouse(94181) N-acetylneuraminic acid synthase (sialic acid synthase)
  • Rat(298071) N-acetylneuraminic acid synthase
  • sheep(101104048) N-acetylneuraminic acid synthase
  • domestic guinea pig(100716456) N-acetylneuraminic acid synthase
  • naked mole-rat(101721582) N-acetylneuraminic acid synthase
  • Domestic Rabbit(100356934) N-acetylneuraminic acid synthase
  • Zebrafish(322780) N-acetylneuraminic acid synthase
  • chicken(427283) N-acetylneuraminic acid synthase
  • domestic cat(101092303) N-acetylneuraminic acid synthase
  • cow(540602) N-acetylneuraminic acid synthase
  • Horse(100064126) N-acetylneuraminic acid synthase
  • dog(481624) N-acetylneuraminic acid synthase

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