Skip to Content
Merck

MDC1

mediator of DNA-damage checkpoint 1

Synonyms:
NFBD1
Species:
Human MDC1 (9656), Mouse Mdc1 (240087), Rat Mdc1 (309595), chicken MDC1 (101664732), chicken MDC1 (101751335), cow MDC1 (511168), Horse MDC1 (100055473), domestic cat MDC1 (101095415), dog MDC1 (474829), sheep MDC1 (101107143) ...More
UniProtKB ID:
Q14676, A2AB04, A2BF04, A2RRA8, A7YY86, B0S8A2, Q0EFC2, Q2L6H7
Gene ID:
  • Human(9656) Summary: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. [provided by RefSeq, Jul 2008]
  • Mouse(240087) mediator of DNA damage checkpoint 1
  • Rat(309595) mediator of DNA damage checkpoint 1
  • chicken(101664732) mediator of DNA-damage checkpoint 1
  • chicken(101751335) mediator of DNA-damage checkpoint 1
  • cow(511168) mediator of DNA-damage checkpoint 1
  • Horse(100055473) mediator of DNA-damage checkpoint 1
  • domestic cat(101095415) mediator of DNA-damage checkpoint 1
  • dog(474829) mediator of DNA-damage checkpoint 1
  • sheep(101107143) mediator of DNA-damage checkpoint 1
  • domestic guinea pig(100721744) mediator of DNA-damage checkpoint 1
  • naked mole-rat(101702518) mediator of DNA-damage checkpoint 1

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
05-1572
Anti-MDC1 Antibody, clone P2B11, clone P2B11, from mouse,
Species Reactivity
bovine, chimpanzee, human, mouse
Application
immunocytochemistry
western blot