LZTFL1
leucine zipper transcription factor-like 1
Synonyms:
BBS17
Species:
Human LZTFL1 (54585), Mouse Lztfl1 (93730), Rat Lztfl1 (316102), sheep LZTFL1 (101118737), naked mole-rat Lztfl1 (101697012), domestic guinea pig Lztfl1 (100715265), Zebrafish lztfl1 (322226), chicken LZTFL1 (420698), domestic cat LZTFL1 (101082984), cow LZTFL1 (512570)
UniProtKB ID:
Gene ID:
- Human(54585) Summary: This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2013]
- Mouse(93730) leucine zipper transcription factor-like 1
- Rat(316102) leucine zipper transcription factor-like 1
- sheep(101118737) leucine zipper transcription factor-like 1
- naked mole-rat(101697012) leucine zipper transcription factor-like 1
- domestic guinea pig(100715265) leucine zipper transcription factor-like 1
- Zebrafish(322226) leucine zipper transcription factor-like 1
- chicken(420698) leucine zipper transcription factor-like 1
- domestic cat(101082984) leucine zipper transcription factor-like 1
- cow(512570) leucine zipper transcription factor-like 1
- dog(476651) leucine zipper transcription factor-like 1
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