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Merck

LMNA

lamin A/C

Synonyms:
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1
Species:
Human LMNA (4000), Mouse Lmna (16905), Rat Lmna (60374), Zebrafish lmna (195815), cow LMNA (404144), Horse LMNA (100057663), domestic cat LMNA (101086199), dog LMNA (480124), chicken LMNA (415464), domestic guinea pig Lmna (100735212) ...More
UniProtKB ID:
P02545, B4DI32, D3DVB0, E7EUI9, P02546, Q5TCJ2, Q5TCJ3, Q969I8
Gene ID:
  • Human(4000) Summary: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]
  • Mouse(16905) lamin A
  • Rat(60374) lamin A/C
  • Zebrafish(195815) lamin A
  • cow(404144) lamin A/C
  • Horse(100057663) lamin A/C
  • domestic cat(101086199) lamin A/C
  • dog(480124) lamin A/C
  • chicken(415464) lamin A/C
  • domestic guinea pig(100735212) lamin A/C
  • naked mole-rat(101704567) lamin A/C
  • sheep(101107924) lamin A/C

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Antibodies

Product Number
Description
Species Reactivity
Application
05-714
Anti-Lamin A/C Antibody, clone 14, clone 14, Upstate®, from mouse,
Species Reactivity
canine, chicken, human, mouse, rat
Application
immunocytochemistry
western blot
MAB3540
Anti-Lamin A Antibody, CT, a.a. 598-611, clone 133A2, clone 133A2, Chemicon®, from mouse,
Species Reactivity
bovine, canine, human, mouse, rat
Application
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
05-1231
Anti-Progerin Antibody, clone 13A4, clone 13A4, Upstate®, from mouse,
Species Reactivity
human
Application
ELISA
immunocytochemistry
immunoprecipitation (IP)
western blot