LAMC2
laminin, gamma 2
Synonyms:
B2T, BM600, CSF, EBR2, EBR2A, LAMB2T, LAMNB2
Species:
Human LAMC2 (3918), Mouse Lamc2 (16782), Rat Lamc2 (192362), sheep LAMC2 (100216328), domestic guinea pig Lamc2 (100733999), naked mole-rat Lamc2 (101719910), chicken LAMC2 (408043), dog LAMC2 (442939), Horse LAMC2 (791245), cow LAMC2 (511043)
UniProtKB ID:
Gene ID:
- Human(3918) Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 2. The gamma 2 chain, formerly thought to be a truncated version of beta chain (B2t), is highly homologous to the gamma 1 chain; however, it lacks domain VI, and domains V, IV and III are shorter. It is expressed in several fetal tissues but differently from gamma 1, and is specifically localized to epithelial cells in skin, lung and kidney. The gamma 2 chain together with alpha 3 and beta 3 chains constitute laminin 5 (earlier known as kalinin), which is an integral part of the anchoring filaments that connect epithelial cells to the underlying basement membrane. The epithelium-specific expression of the gamma 2 chain implied its role as an epithelium attachment molecule, and mutations in this gene have been associated with junctional epidermolysis bullosa, a skin disease characterized by blisters due to disruption of the epidermal-dermal junction. Two transcript variants resulting from alternative splicing of the 3' terminal exon, and encoding different isoforms of gamma 2 chain, have been described. The two variants are differentially expressed in embryonic tissues, however, the biological significance of the two forms is not known. Transcript variants utilizing alternative polyA_signal have also been noted in literature. [provided by RefSeq, Aug 2011]
- Mouse(16782) laminin, gamma 2
- Rat(192362) laminin, gamma 2
- sheep(100216328) laminin, gamma 2
- domestic guinea pig(100733999) laminin, gamma 2
- naked mole-rat(101719910) laminin, gamma 2
- chicken(408043) laminin, gamma 2
- dog(442939) laminin, gamma 2
- Horse(791245) laminin, gamma 2
- cow(511043) laminin, gamma 2
- domestic cat(101089571) laminin, gamma 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Laminin-5 Antibody, clone P3E4, clone P3E4, Chemicon®, from mouse,
Species Reactivity
human
Application
ELISA
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-Laminin-5 Antibody, clone D4B5, Alexa Fluor™ 488 conjugated, clone D4B5, Chemicon®, from mouse,
Species Reactivity
human
Application
flow cytometry
immunocytochemistry
immunocytochemistry
Anti-Laminin-5 (γ2 chain) Antibody, clone D4B5, clone D4B5, Chemicon®, from mouse,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Proteins
Product Number
Description
Species
Laminin from Engelbreth-Holm-Swarm murine sarcoma basement membrane, 1-2 mg/mL in Tris-buffered saline, 0.2 μm filtered, BioReagent, suitable for cell culture,
Species
mouse
ECM Gel from Engelbreth-Holm-Swarm murine sarcoma, liquid, BioReagent, suitable for cell culture,
Species
mouse