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Merck

KLK2

kallikrein-related peptidase 2

Synonyms:
KLK2A2, hGK-1, hK2
Species:
Human KLK2 (3817), dog KLK2 (403967), domestic guinea pig Klk2 (100716976)
UniProtKB ID:
P20151, B4DU93, B4DUB0, F5H8L3, Q15946, Q9UJZ9
Gene ID:
  • Human(3817) Summary: This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
  • dog(403967) kallikrein-related peptidase 2
  • domestic guinea pig(100716976) kallikrein-related peptidase 2

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