IL4R
interleukin 4 receptor
Synonyms:
CD124, IL-4RA, IL4RA
Species:
Human IL4R (3566), Rat Il4r (25084), sheep IL4R (101109063), Domestic Rabbit IL4R (100337721), domestic guinea pig Il4r (100721566), naked mole-rat Il4r (101704138), Zebrafish il4r (503594), chicken IL4R (416585), cow IL4R (404154), Horse IL4R (791252) ...More
UniProtKB ID:
Gene ID:
- Human(3566) Summary: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]
- Rat(25084) interleukin 4 receptor
- sheep(101109063) interleukin 4 receptor
- Domestic Rabbit(100337721) interleukin 4 receptor
- domestic guinea pig(100721566) interleukin 4 receptor
- naked mole-rat(101704138) interleukin 4 receptor
- Zebrafish(503594) interleukin 4 receptor
- chicken(416585) interleukin 4 receptor
- cow(404154) interleukin 4 receptor
- Horse(791252) interleukin 4 receptor
- domestic cat(101096277) interleukin 4 receptor
- dog(489957) interleukin 4 receptor
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