IL1B
interleukin 1, beta
Synonyms:
IL-1, IL1-BETA, IL1F2
Species:
Human IL1B (3553), Mouse Il1b (16176), Rat Il1b (24494), Zebrafish il1b (557541), domestic cat IL1B (768274), cow IL1B (281251), Horse IL1B (100034237), dog IL1B (403974), Zebrafish il1b (405770), chicken IL1B (395196) ...More
UniProtKB ID:
Gene ID:
- Human(3553) Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008]
- Mouse(16176) interleukin 1 beta
- Rat(24494) interleukin 1 beta
- Zebrafish(557541) interleukin 1, beta
- domestic cat(768274) interleukin 1, beta
- cow(281251) interleukin 1, beta
- Horse(100034237) interleukin 1, beta
- dog(403974) interleukin 1, beta
- Zebrafish(405770) interleukin 1, beta
- chicken(395196) interleukin 1, beta
- Goat(100860816) interleukin 1, beta
- Domestic Rabbit(100008990) interleukin 1, beta
- domestic guinea pig(100135556) interleukin 1 beta
- naked mole-rat(101704309) interleukin 1, beta
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