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Merck

IDH1

isocitrate dehydrogenase 1 (NADP+), soluble

Synonyms:
IDCD, IDH, IDP, IDPC, PICD
Species:
UniProtKB ID:
Gene ID:
  • Human(3417) Summary: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008]
  • Mouse(15926) isocitrate dehydrogenase 1 (NADP+), soluble
  • Rat(24479) isocitrate dehydrogenase 1 (NADP+), soluble
  • Zebrafish(100006589) isocitrate dehydrogenase 1 (NADP+), soluble
  • chicken(424112) isocitrate dehydrogenase 1 (NADP+), soluble
  • dog(478889) isocitrate dehydrogenase 1 (NADP+), soluble
  • domestic cat(751618) isocitrate dehydrogenase 1 (NADP+), soluble
  • cow(281235) isocitrate dehydrogenase 1 (NADP+), soluble
  • Horse(100066416) isocitrate dehydrogenase 1 (NADP+), soluble
  • Thale Cress(829679) Isocitrate dehydrogenase [NAD] regulatory subunit 1
  • sheep(443257) isocitrate dehydrogenase 1 (NADP+), soluble
  • Domestic Rabbit(100328559) isocitrate dehydrogenase 1 (NADP+), soluble
  • domestic guinea pig(100729107) isocitrate dehydrogenase 1 (NADP+), soluble
  • naked mole-rat(101705662) isocitrate dehydrogenase 1 (NADP+), soluble

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