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HRAS

Harvey rat sarcoma viral oncogene homolog

Synonyms:
C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1
Species:
Human HRAS (3265), Rat Hras (293621), chicken HRAS (396229), dog HRAS (403735), cow HRAS (100298939), sheep HRAS (101104357), domestic guinea pig Hras (100735038), naked mole-rat Hras (101716053)
UniProtKB ID:
P01112, B5BUA0, Q14080, Q6FHV9, Q9BR65, Q9UCE2
Gene ID:
  • Human(3265) Summary: This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Rat(293621) Harvey rat sarcoma virus oncogene
  • chicken(396229) v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • dog(403735) v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • cow(100298939) v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • sheep(101104357) v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • domestic guinea pig(100735038) v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • naked mole-rat(101716053) v-Ha-ras Harvey rat sarcoma viral oncogene homolog

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Antibodies

Product Number
Description
Species Reactivity
Application
05-1072
Anti-Ras Antibody, (K-, H-, N-), clone 9A11.2, clone 9A11.2, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
05-516
Anti-Ras Antibody, clone RAS10, clone RAS10, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
ELISA
flow cytometry
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot