HDAC5
histone deacetylase 5
Synonyms:
HD5, NY-CO-9
Species:
Human HDAC5 (10014), Mouse Hdac5 (15184), Rat Hdac5 (84580), sheep HDAC5 (101113686), domestic guinea pig Hdac5 (100722799), naked mole-rat Hdac5 (101721186), cow HDAC5 (504242), domestic cat HDAC5 (101098019), dog HDAC5 (490941)
UniProtKB ID:
Gene ID:
- Human(10014) Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(15184) histone deacetylase 5
- Rat(84580) histone deacetylase 5
- sheep(101113686) histone deacetylase 5
- domestic guinea pig(100722799) histone deacetylase 5
- naked mole-rat(101721186) histone deacetylase 5
- cow(504242) histone deacetylase 5
- domestic cat(101098019) histone deacetylase 5
- dog(490941) histone deacetylase 5
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-HDAC5 Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot