GRM4
glutamate receptor, metabotropic 4
Synonyms:
GPRC1D, MGLUR4, mGlu4
Species:
Human GRM4 (2914), Mouse Grm4 (268934), Rat Grm4 (24417), sheep GRM4 (101119427), domestic guinea pig Grm4 (100727790), naked mole-rat Grm4 (101704191), Zebrafish grm4 (567181), cow GRM4 (790333), domestic cat GRM4 (101094419), dog GRM4 (481749)
UniProtKB ID:
Gene ID:
- Human(2914) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
- Mouse(268934) glutamate receptor, metabotropic 4
- Rat(24417) glutamate receptor, metabotropic 4
- sheep(101119427) glutamate receptor, metabotropic 4
- domestic guinea pig(100727790) glutamate receptor, metabotropic 4
- naked mole-rat(101704191) glutamate receptor, metabotropic 4
- Zebrafish(567181) glutamate receptor, metabotropic 4
- cow(790333) glutamate receptor, metabotropic 4
- domestic cat(101094419) glutamate receptor, metabotropic 4
- dog(481749) glutamate receptor, metabotropic 4
- chicken(419906) glutamate receptor, metabotropic 4
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