GHR
growth hormone receptor
Synonyms:
GHBP
Species:
Human GHR (2690), Mouse Ghr (14600), Rat Ghr (25235), chicken GHR (408184), cow GHR (280805), domestic cat GHR (101093244), dog GHR (403721), naked mole-rat Ghr (101716037), domestic guinea pig Ghr (100135527), Goat GHR (100860790) ...More
UniProtKB ID:
Gene ID:
- Human(2690) Summary: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
- Mouse(14600) growth hormone receptor
- Rat(25235) growth hormone receptor
- chicken(408184) growth hormone receptor
- cow(280805) growth hormone receptor
- domestic cat(101093244) growth hormone receptor
- dog(403721) growth hormone receptor
- naked mole-rat(101716037) growth hormone receptor
- domestic guinea pig(100135527) growth hormone receptor
- Goat(100860790) growth hormone receptor
- Domestic Rabbit(100009325) growth hormone receptor
- sheep(443333) growth hormone receptor
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