GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
Synonyms:
Species:
Human GABRA4 (2557), Mouse Gabra4 (14397), Rat Gabra4 (140675), domestic guinea pig Gabra4 (100721252), naked mole-rat Gabra4 (101718327), sheep GABRA4 (101121776), Domestic Rabbit GABRA4 (100339882), chicken GABRA4 (422770), dog GABRA4 (482132), cow GABRA4 (282238)
UniProtKB ID:
Gene ID:
- Human(2557) Summary: Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. This gene encodes subunit alpha-4, which is involved in the etiology of autism and eventually increases autism risk through interaction with another subunit, gamma-aminobutyric acid receptor beta-1 (GABRB1). Alternatively spliced transcript variants encoding different isoforms have been found in this gene.[provided by RefSeq, Feb 2011]
- Mouse(14397) gamma-aminobutyric acid (GABA) A receptor, subunit alpha 4
- Rat(140675) gamma-aminobutyric acid (GABA) A receptor, alpha 4
- domestic guinea pig(100721252) gamma-aminobutyric acid (GABA) A receptor, alpha 4
- naked mole-rat(101718327) gamma-aminobutyric acid (GABA) A receptor, alpha 4
- sheep(101121776) gamma-aminobutyric acid (GABA) A receptor, alpha 4
- Domestic Rabbit(100339882) gamma-aminobutyric acid (GABA) A receptor, alpha 4
- chicken(422770) gamma-aminobutyric acid (GABA) A receptor, alpha 4
- dog(482132) gamma-aminobutyric acid (GABA) A receptor, alpha 4
- cow(282238) gamma-aminobutyric acid (GABA) A receptor, alpha 4
- domestic cat(101098052) gamma-aminobutyric acid (GABA) A receptor, alpha 4
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Small Molecule - Agonist
Product Number
Description
Species
Small Molecule - Allosteric Modulator
Product Number
Description
Species
Lorazepam for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Oxazepam for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
Small Molecule - Antagonist
Product Number
Description
Species
Acamprosate calcium, United States Pharmacopeia (USP) Reference Standard, monograph mol wt. 400.48 (C10H20CaN2O8S2),
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-GABA A Receptor α4 Antibody, CT, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot