FADD
Fas (TNFRSF6)-associated via death domain
Synonyms:
MORT1
Species:
Human FADD (8772), Mouse Fadd (14082), Rat Fadd (266610), Zebrafish fadd (562317), chicken FADD (423146), dog FADD (611694), cow FADD (493720), domestic guinea pig Fadd (100730628), naked mole-rat Fadd (101709972), sheep FADD (101116783)
UniProtKB ID:
Gene ID:
- Human(8772) Summary: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
- Mouse(14082) Fas (TNFRSF6)-associated via death domain
- Rat(266610) Fas (TNFRSF6)-associated via death domain
- Zebrafish(562317) Fas (tnfrsf6)-associated via death domain
- chicken(423146) Fas (TNFRSF6)-associated via death domain
- dog(611694) Fas (TNFRSF6)-associated via death domain
- cow(493720) Fas (TNFRSF6)-associated via death domain
- domestic guinea pig(100730628) Fas (TNFRSF6)-associated via death domain
- naked mole-rat(101709972) Fas (TNFRSF6)-associated via death domain
- sheep(101116783) Fas (TNFRSF6)-associated via death domain
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