DMBT1
deleted in malignant brain tumors 1
Synonyms:
GP340, muclin
Species:
Human DMBT1 (1755), Mouse Dmbt1 (12945), Rat Dmbt1 (170568), domestic guinea pig Dmbt1 (100715944), naked mole-rat Dmbt1 (101702699), Domestic Rabbit DMBT1 (100008679), chicken DMBT1 (426819), dog DMBT1 (486922), domestic cat DMBT1 (101096171), cow DMBT1 (404104)
UniProtKB ID:
Gene ID:
- Human(1755) Summary: Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system. [provided by RefSeq, Jul 2008]
- Mouse(12945) deleted in malignant brain tumors 1
- Rat(170568) deleted in malignant brain tumors 1
- domestic guinea pig(100715944) deleted in malignant brain tumors 1
- naked mole-rat(101702699) deleted in malignant brain tumors 1
- Domestic Rabbit(100008679) deleted in malignant brain tumors 1
- chicken(426819) deleted in malignant brain tumors 1
- dog(486922) deleted in malignant brain tumors 1
- domestic cat(101096171) deleted in malignant brain tumors 1
- cow(404104) deleted in malignant brain tumors 1
- Horse(100064515) deleted in malignant brain tumors 1
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