DERL1
derlin 1
Synonyms:
DER-1, DER1
Species:
Human DERL1 (79139), Mouse Derl1 (67819), Rat Derl1 (362912), naked mole-rat Derl1 (101722706), domestic guinea pig Derl1 (100727484), Zebrafish derl1 (406753), dog DERL1 (475086), cow DERL1 (404121), domestic cat DERL1 (101100445), chicken DERL1 (420350)
UniProtKB ID:
Gene ID:
- Human(79139) Summary: The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
- Mouse(67819) Der1-like domain family, member 1
- Rat(362912) derlin 1
- naked mole-rat(101722706) derlin 1
- domestic guinea pig(100727484) derlin 1
- Zebrafish(406753) Der1-like domain family, member 1
- dog(475086) derlin 1
- cow(404121) derlin 1
- domestic cat(101100445) derlin 1
- chicken(420350) derlin 1
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