DAAM1
dishevelled associated activator of morphogenesis 1
Synonyms:
Species:
Human DAAM1 (23002), Mouse Daam1 (208846), Rat Daam1 (314212), chicken DAAM1 (423532), dog DAAM1 (490714), domestic cat DAAM1 (101098546), Horse DAAM1 (100051203), cow DAAM1 (513742), domestic guinea pig Daam1 (100719981), naked mole-rat Daam1 (101726077)
UniProtKB ID:
Gene ID:
- Human(23002) Summary: Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]
- Mouse(208846) dishevelled associated activator of morphogenesis 1
- Rat(314212) dishevelled associated activator of morphogenesis 1
- chicken(423532) dishevelled associated activator of morphogenesis 1
- dog(490714) dishevelled associated activator of morphogenesis 1
- domestic cat(101098546) dishevelled associated activator of morphogenesis 1
- Horse(100051203) dishevelled associated activator of morphogenesis 1
- cow(513742) dishevelled associated activator of morphogenesis 1
- domestic guinea pig(100719981) dishevelled associated activator of morphogenesis 1
- naked mole-rat(101726077) dishevelled associated activator of morphogenesis 1
- sheep(101123636) dishevelled associated activator of morphogenesis 1
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