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Merck

CRH

corticotropin releasing hormone

Synonyms:
CRF
Species:
Human CRH (1392), Mouse Crh (12918), Rat Crh (81648), chicken CRH (404297), dog CRH (486977), domestic cat CRH (692345), cow CRH (280755), sheep CRH (101121525), Domestic Rabbit CRH (100301553), domestic guinea pig Crh (100719294)
UniProtKB ID:
P06850, B3KQS4
Gene ID:
  • Human(1392) Summary: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]
  • Mouse(12918) corticotropin releasing hormone
  • Rat(81648) corticotropin releasing hormone
  • chicken(404297) corticotropin releasing hormone
  • dog(486977) corticotropin releasing hormone
  • domestic cat(692345) corticotropin releasing hormone
  • cow(280755) corticotropin releasing hormone
  • sheep(101121525) corticotropin releasing hormone
  • Domestic Rabbit(100301553) corticotropin releasing hormone
  • domestic guinea pig(100719294) corticotropin releasing hormone
  • naked mole-rat(101717831) corticotropin releasing hormone

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