CLDN18
claudin 18
Synonyms:
SFTA5, SFTPJ
Species:
Human CLDN18 (51208), Mouse Cldn18 (56492), Rat Cldn18 (315953), chicken CLDN18 (429135), domestic cat CLDN18 (101093797), cow CLDN18 (511460), dog CLDN18 (477079), sheep CLDN18 (101112106), domestic guinea pig Cldn18 (100730947), naked mole-rat Cldn18 (101705422)
UniProtKB ID:
Gene ID:
- Human(51208) Summary: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
- Mouse(56492) claudin 18
- Rat(315953) claudin 18
- chicken(429135) claudin 18
- domestic cat(101093797) claudin 18
- cow(511460) claudin 18
- dog(477079) claudin 18
- sheep(101112106) claudin 18
- domestic guinea pig(100730947) claudin 18
- naked mole-rat(101705422) claudin 18
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