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Merck

CHRM1

cholinergic receptor, muscarinic 1

Synonyms:
HM1, M1, M1R
Species:
Human CHRM1 (1128), Mouse Chrm1 (12669), Rat Chrm1 (25229), cow CHRM1 (281684), Horse CHRM1 (100064117), domestic cat CHRM1 (101093801), domestic cat CHRM1 (493664), dog CHRM1 (483776), naked mole-rat Chrm1 (101702102), domestic guinea pig Chrm1 (100728041)
UniProtKB ID:
P11229
Gene ID:
  • Human(1128) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
  • Mouse(12669) cholinergic receptor, muscarinic 1, CNS
  • Rat(25229) cholinergic receptor, muscarinic 1
  • cow(281684) cholinergic receptor, muscarinic 1
  • Horse(100064117) cholinergic receptor, muscarinic 1
  • domestic cat(101093801) cholinergic receptor, muscarinic 1
  • domestic cat(493664) cholinergic receptor, muscarinic 1
  • dog(483776) cholinergic receptor, muscarinic 1
  • naked mole-rat(101702102) cholinergic receptor, muscarinic 1
  • domestic guinea pig(100728041) cholinergic receptor, muscarinic 1
  • sheep(101117029) cholinergic receptor, muscarinic 1

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Small Molecule - Agonist

Product Number
Description
Species
1539009
Pilocarpine nitrate, United States Pharmacopeia (USP) Reference Standard,
Species
human
P1700000
Pilocarpine nitrate, European Pharmacopoeia (EP) Reference Standard,
Species
human
BP503
Pilocarpine nitrate, British Pharmacopoeia (BP) Reference Standard,
Species
human
PHL80370
Pilocarpine hydrochloride, phyproof® Reference Substance,
Species
human
1538902
Pilocarpine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
B1120000
Biperiden hydrochloride, European Pharmacopoeia (EP) Reference Standard,
Species
human
BP036
Benzatropine mesilate, British Pharmacopoeia (BP) Reference Standard,
Species
human
1567004
Procyclidine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
1610001
Scopolamine hydrobromide, United States Pharmacopeia (USP) Reference Standard,
Species
human
BP296
Procyclidine hydrochloride, British Pharmacopoeia (BP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
AB5164
Anti-Muscarinic Acetylcholine Receptor m1 Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse, rat
Application
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
A8404
Amitriptyline hydrochloride, ≥98% (TLC), powder,
Species
human

Proteins

Product Number
Description
Species
HTS044RTA
Ready-to-Assay M1 Acetylcholine (Muscarinic) Family Receptor Frozen Cells, ,
Species
human
HTS044M
ChemiScreen Membrane Preparation Human Recombinant M1 Muscarinic Acetylcholine Receptor, Human M1 GPCR membrane prepation for Radioligand binding Assays.,
Species
human