CENPJ
centromere protein J
Synonyms:
BM032, CENP-J, CPAP, LAP, LIP1, MCPH6, SASS4, SCKL4, Sas-4
Species:
Human CENPJ (55835), Mouse Cenpj (219103), Rat Cenpj (305909), Zebrafish cenpj (568957), chicken CENPJ (418960), dog CENPJ (486055), domestic cat CENPJ (101081107), Horse CENPJ (100049819), cow CENPJ (613543), sheep CENPJ (101119996) ...More
UniProtKB ID:
Gene ID:
- Human(55835) Summary: This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
- Mouse(219103) centromere protein J
- Rat(305909) centromere protein J
- Zebrafish(568957) centromere protein J
- chicken(418960) centromere protein J
- dog(486055) centromere protein J
- domestic cat(101081107) centromere protein J
- Horse(100049819) centromere protein J
- cow(613543) centromere protein J
- sheep(101119996) centromere protein J
- domestic guinea pig(100712775) centromere protein J
- naked mole-rat(101715831) centromere protein J
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