CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Synonyms:
CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
Species:
Human CDK5R1 (8851), Mouse Cdk5r1 (12569), Rat Cdk5r1 (116671), dog CDK5R1 (491154), cow CDK5R1 (282173), domestic cat CDK5R1 (101094890), naked mole-rat Cdk5r1 (101725041), domestic guinea pig Cdk5r1 (100718674), sheep CDK5R1 (101120847)
UniProtKB ID:
Gene ID:
- Human(8851) Summary: The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]
- Mouse(12569) cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- Rat(116671) cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- dog(491154) cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- cow(282173) cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- domestic cat(101094890) cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- naked mole-rat(101725041) cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- domestic guinea pig(100718674) cyclin-dependent kinase 5, regulatory subunit 1 (p35)
- sheep(101120847) cyclin-dependent kinase 5, regulatory subunit 1 (p35)
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