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Merck

BIN1

bridging integrator 1

Synonyms:
AMPH2, AMPHL, SH3P9
Species:
Human BIN1 (274), Mouse Bin1 (30948), Rat Bin1 (117028), Zebrafish bin1 (447863), Horse BIN1 (100052213), cow BIN1 (614576), domestic cat BIN1 (101097908), fruit fly Bin1 (41965), dog BIN1 (483870), chicken BIN1 (424228) ...More
UniProtKB ID:
O00499, O00297, O00545, O43867, O60552, O60553, O60554, O60555
Gene ID:
  • Human(274) Summary: This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Sep 2011]
  • Mouse(30948) bridging integrator 1
  • Rat(117028) bridging integrator 1
  • Zebrafish(447863) bridging integrator 1
  • Horse(100052213) bridging integrator 1
  • cow(614576) bridging integrator 1
  • domestic cat(101097908) bridging integrator 1
  • fruit fly(41965) Bicoid interacting protein 1
  • dog(483870) bridging integrator 1
  • chicken(424228) bridging integrator 1
  • domestic guinea pig(100722858) bridging integrator 1
  • naked mole-rat(101723039) bridging integrator 1
  • sheep(101119119) bridging integrator 1

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Antibodies

Product Number
Description
Species Reactivity
Application
05-449
Anti-Bin1 Antibody, clone 99D, clone 99D, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot