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Merck

ATP6V1B1

ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1

Synonyms:
ATP6B1, RTA1B, VATB, VMA2, VPP3
Species:
Human ATP6V1B1 (525), Mouse Atp6v1b1 (110935), Rat Atp6v1b1 (312488), domestic cat ATP6V1B1 (101098295), cow ATP6V1B1 (338059), Horse ATP6V1B1 (100050282), dog ATP6V1B1 (474628), sheep ATP6V1B1 (101107683), domestic guinea pig Atp6v1b1 (100724011), naked mole-rat Atp6v1b1 (101720999)
UniProtKB ID:
P15313, Q53FY0, Q6P4H6
Gene ID:
  • Human(525) Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq, Jul 2008]
  • Mouse(110935) ATPase, H+ transporting, lysosomal V1 subunit B1
  • Rat(312488) ATPase, H transporting, lysosomal V1 subunit B1
  • domestic cat(101098295) ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
  • cow(338059) ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
  • Horse(100050282) ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
  • dog(474628) ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
  • sheep(101107683) ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
  • domestic guinea pig(100724011) ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1
  • naked mole-rat(101720999) ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1

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