ATF6
activating transcription factor 6
Synonyms:
ATF6A
Species:
Human ATF6 (22926), Mouse Atf6 (226641), Rat Atf6 (304962), Zebrafish atf6 (558071), cow ATF6 (530610), Horse ATF6 (100051169), domestic cat ATF6 (101086780), dog ATF6 (488660), chicken ATF6 (424365), fruit fly Atf6 (35480) ...More
UniProtKB ID:
Gene ID:
- Human(22926) Summary: This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]
- Mouse(226641) activating transcription factor 6
- Rat(304962) activating transcription factor 6
- Zebrafish(558071) activating transcription factor 6
- cow(530610) activating transcription factor 6
- Horse(100051169) activating transcription factor 6
- domestic cat(101086780) activating transcription factor 6
- dog(488660) activating transcription factor 6
- chicken(424365) activating transcription factor 6
- fruit fly(35480) CG3136 gene product from transcript CG3136-RA
- sheep(541606) activating transcription factor 6
- Domestic Rabbit(100358536) activating transcription factor 6
- domestic guinea pig(100730337) activating transcription factor 6
- naked mole-rat(101706597) activating transcription factor 6
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