ARHGAP35
Rho GTPase activating protein 35
Synonyms:
GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP
Species:
Human ARHGAP35 (2909), Rat Arhgap35 (306400), Zebrafish arhgap35 (564565), cow ARHGAP35 (540310), chicken ARHGAP35 (425730), dog ARHGAP35 (403543), domestic cat ARHGAP35 (101089912), sheep ARHGAP35 (101117354), domestic guinea pig Arhgap35 (100718086), naked mole-rat Arhgap35 (101719355)
UniProtKB ID:
Gene ID:
- Human(2909) Summary: The human glucocorticoid receptor DNA binding factor, which associates with the promoter region of the glucocorticoid receptor gene (hGR gene), is a repressor of glucocorticoid receptor transcription. The amino acid sequence deduced from the cDNA sequences show the presence of three sequence motifs characteristic of a zinc finger and one motif suggestive of a leucine zipper in which 1 cysteine is found instead of all leucines. The GRLF1 enhances the homologous down-regulation of wild-type hGR gene expression. Biochemical analysis suggests that GRLF1 interaction is sequence specific and that transcriptional efficacy of GRLF1 is regulated through its interaction with specific sequence motif. The level of expression is regulated by glucocorticoids. [provided by RefSeq, Jul 2008]
- Rat(306400) Rho GTPase activating protein 35
- Zebrafish(564565) Rho GTPase activating protein 35b
- cow(540310) Rho GTPase activating protein 35
- chicken(425730) Rho GTPase activating protein 35
- dog(403543) Rho GTPase activating protein 35
- domestic cat(101089912) Rho GTPase activating protein 35
- sheep(101117354) Rho GTPase activating protein 35
- domestic guinea pig(100718086) Rho GTPase activating protein 35
- naked mole-rat(101719355) Rho GTPase activating protein 35
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