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Merck

AR

androgen receptor

Synonyms:
AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Species:
UniProtKB ID:
Gene ID:
  • Human(367) Summary: The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
  • Mouse(11835) androgen receptor
  • Rat(24208) androgen receptor
  • Zebrafish(100005148) androgen receptor
  • chicken(422165) androgen receptor
  • fruit fly(44503) abdomen rotatum
  • domestic cat(101081787) androgen receptor
  • cow(280675) androgen receptor
  • Horse(100033980) androgen receptor
  • domestic cat(751827) androgen receptor
  • dog(403588) androgen receptor
  • Goat(100860827) androgen receptor
  • Domestic Rabbit(100009193) androgen receptor
  • sheep(443042) androgen receptor
  • domestic guinea pig(100726891) androgen receptor

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Small Molecule - Activator

Product Number
Description
Species
Propylene glycol monomethyl ether acetate, ReagentPlus®, ≥99.5%,
Species
human
Resveratrol, ≥99% (HPLC),
Species
human, rat, mouse
β-Estradiol, BioReagent, powder, suitable for cell culture,
Species
human, mouse, rat
Mifepristone, ≥98%,
Species
human, mouse, rat

Small Molecule - Agonist

Product Number
Description
Species
Methyltestosterone, United States Pharmacopeia (USP) Reference Standard,
Species
human
17α-Methyltestosterone, ≥97.0% (HPLC),
Species
human, rat
Testosterone propionate, tested according to Ph. Eur.,
Species
human, rat
Testosterone propionate, solid,
Species
human, rat
Hydrocortisone-Water Soluble, BioReagent, suitable for cell culture,
Species
human, mouse, rat

Small Molecule - Antagonist

Product Number
Description
Species
Vanillin, natural, ≥97%, FCC, FG,
Species
rat
Isoeugenol, mixture of cis and trans, 99%, FG,
Species
rat
2,4-Dihydroxybenzophenone, 99%,
Species
rat
4-Phenylphenol, purified by sublimation, 99%,
Species
rat
Vanillin, ReagentPlus®, 99%,
Species
rat

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-phospho-Androgen Receptor (Ser81) Antibody, rabbit monoclonal, culture supernatant, Upstate®,
Species Reactivity
human
Application
western blot
Anti-phospho-Androgen Receptor (Ser81) Antibody, Upstate®, from rabbit,
Species Reactivity
bovine, dog, horse, human, primate
Application
western blot
Anti-Androgen Receptor Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, canine, horse, human, mouse, rat
Application
ChIP
flow cytometry

immunocytochemistry

immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

Product Number
Description
Species
Testosterone propionate, tested according to Ph. Eur.,
Species
human, rat
Testosterone propionate, solid,
Species
human, rat
Cholesterol, Sigma Grade, ≥99%,
Species
rat, human
Propylene glycol monomethyl ether acetate, ReagentPlus®, ≥99.5%,
Species
human
Corticosterone, ≥92%,
Species
rat, human

Small Molecule - Ligand

Product Number
Description
Species
Testosterone, purum, ≥99.0% (HPLC),
Species
human
Tamoxifen, ≥99%,
Species
human, rat
Progesterone, powder, BioReagent, suitable for cell culture,
Species
mouse, human, rat