ADORA2A
adenosine A2a receptor
Synonyms:
A2aR, ADORA2, RDC8
Species:
Human ADORA2A (135), Mouse Adora2a (11540), Rat Adora2a (25369), sheep ADORA2A (101112926), naked mole-rat Adora2a (101718082), domestic guinea pig Adora2a (100135473), chicken ADORA2A (427705), dog ADORA2A (403960), cow ADORA2A (617828), Horse ADORA2A (100034039)
UniProtKB ID:
Gene ID:
- Human(135) Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
- Mouse(11540) adenosine A2a receptor
- Rat(25369) adenosine A2a receptor
- sheep(101112926) adenosine A2a receptor
- naked mole-rat(101718082) adenosine A2a receptor
- domestic guinea pig(100135473) adenosine A2a receptor
- chicken(427705) adenosine A2a receptor
- dog(403960) adenosine A2a receptor
- cow(617828) adenosine A2a receptor
- Horse(100034039) adenosine A2a receptor
- domestic cat(101080742) adenosine A2a receptor
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Small Molecule - Antagonist
Product Number
Description
Species
Caffeine, certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland,
Species
human
Caffeine melting point standard, United States Pharmacopeia (USP) Reference Standard,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Adenosine A2a Receptor Antibody, Chemicon®, from rabbit,
Species Reactivity
bovine, canine, human, pig
Application
ELISA
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-Adenosine A2a Receptor Antibody, serum, Chemicon®,
Species Reactivity
bovine, canine, human, pig, rat
Application
ELISA
western blot
western blot
Anti-Adenosine Receptor A2a Antibody, clone 7F6-G5-A2, clone 7F6-G5-A2, Upstate®, from mouse,
Species Reactivity
canine, dog, human, mouse, rabbit, rat
Application
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
Product Number
Description
Species
Small Molecule - Ligand
Product Number
Description
Species