ACVR2B
activin A receptor, type IIB
Synonyms:
ACTRIIB, ActR-IIB, HTX4
Species:
Human ACVR2B (93), Mouse Acvr2b (11481), Rat Acvr2b (25366), Zebrafish acvr2b (30457), dog ACVR2B (485590), cow ACVR2B (282131), Horse ACVR2B (100053588), domestic cat ACVR2B (101086087), chicken ACVR2B (374213), naked mole-rat Acvr2b (101711703) ...More
UniProtKB ID:
Gene ID:
- Human(93) Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008]
- Mouse(11481) activin receptor IIB
- Rat(25366) activin A receptor, type IIB
- Zebrafish(30457) activin receptor IIb
- dog(485590) activin A receptor, type IIB
- cow(282131) activin A receptor, type IIB
- Horse(100053588) activin A receptor, type IIB
- domestic cat(101086087) activin A receptor, type IIB
- chicken(374213) activin A receptor, type IIB
- naked mole-rat(101711703) activin A receptor, type IIB
- domestic guinea pig(100722791) activin A receptor, type IIB
- sheep(443156) activin A receptor, type IIB
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