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Merck

Complete LC-MS Analysis
for Consistent Results

We provide a premier selection of proven analytical tools and consumables that meet the requirements of scientists who primarily use the liquid chromatography-mass spectrometry (LC-MS) technique for separation and analysis of drugs and biomolecules, or for analytical assays. Our selection of columns, solvents, standards and sample preparation products are exclusively designed for LC-MS, meeting the critical need for purity. You can also find LC-MS applications and method development advice, in addition to comprehensive overviews of our product offerings for both small and large molecule LC-MS workflows, below.

Workflow

Sample Collection

Sample Collection

Sample Preparation

Sample Preparation

Standardization and Calibration

Standardization and Calibration

Chromatographic Separation & Analysis

Chromatographic Separation & Analysis

Chromatographic and Separation Analysis - Featured Articles

Sample Collection and Preparation - Featured Articles

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Related Product Categories
Liquid Handling & Dispensing
We offer an extensive portfolio of serological pipets and pipet controllers for molecular biology and cell culture, Pasteur and transfer pipets for general lab applications, volumetric pipets for titrations and analytical chemistry, and micropipette devices and pipette tips for your lab's liquid dispensing and liquid handling needs.
HPLC Columns
Achieve precise separations with our extensive HPLC column collection. Enhance retention, resolution, and selectivity. Order today.
Solvents
Your Solvent Source: Find the right fit with Supelco®, SigmaAldrich®, & SAFC® brands, covering analytical, lab, & biopharmaceutical uses. Order online.
Chromatography Standards
Certified Reference Materials & reference standards for chromatography-based testing applications including forensic and clinical toxicology analysis, diagnostic testing, therapeutic drug monitoring, cannabis testing, environmental analysis, pharmaceutical research, and food & beverage testing.
Milli-Q® Benchtop Lab Water Purification Systems
Find the water purification system that fits your lab’s needs. Compact Milli-Q® pure and ultrapure benchtop systems can meet your application, quality, volume, space and budget requirements.
Certified Reference Materials
Browse our Certified Reference Materials (CRMs) for applications in forensic and clinical toxicology analysis, diagnostic testing, therapeutic drug monitoring, cannabis testing, environmental analysis, pharmaceutical research, and food & beverage testing.
Chromatography & Spectroscopy Reagents
Explore our selection of high-quality analytical reagents for wet chemistry, chromatography, spectroscopy, analytical, titration, water quality control, and electrochemistry.
Related Applications
Solid Phase Extraction (SPE)
Solid phase extraction purifies samples for chromatographic analysis, improving data quality and protecting analytical columns.
QuEChERS Sample Prep Method
QuEChERS is a ‘Quick, Easy, Cheap, Effective, Rugged and Safe’ sample cleanup method used to prepare food and agricultural samples for pesticides analysis. QuEChERS is based on the Solid Phase Extraction (SPE) technique of sample preparation.
Sample Preparation by Filtration
Filtration separates substances to reduce sample complexity and increase analyte purity, improving analytical results.
Sample Purification
Purification methods for downstream analysis reduce sample complexity, remove interferences, and concentrate analytes for more accurate results.
Small Molecule HPLC
Small molecules are ions and compounds of molecular weight typically less than 900 daltons. These compounds can be effectively separated and analyzed by HPLC, UHPLC and LC-MS using mainly silica particles or monolithic stationary phases with a broad range of column chemistries (modifications).
Large Molecule HPLC
HPLC separates and identifies large biomolecules like proteins and peptides by pumping the sample through a sorbent-packed column.
Mass Spectrometry
Mass spectrometry (MS) is an analytical tool used to identify compounds, determine chemical structure, and assess isotopic abundance. In MS, samples are ionized, and the resulting ions are identified based on their mass-to-charge (m/z) ratios.
mRNA Therapeutics
Our comprehensive portfolio of products and services provides everything you need for mRNA synthesis, purification, and formulation for development and manufacturing.
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Custom Reference Materials
Browse for high-quality Custom Reference Materials tailored to your specific analytical applications from Supelco. Get your quote now!
Custom HPLC Column Request
Supelco offers custom packed HPLC columns for challenging applications; order non-stock product columns with various particle and chemistry options.
Inventory Management
Cerilliant® team provides custom packaging, inventory storage, management, and worldwide distribution of client reference materials.
Custom SPE Tubes & 96-Well Plates
Solid-phase extraction (SPE) offers rapid sample preparation and purification for chromatographic analysis, customizable to analytical needs.
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