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Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

Poly(anhydride-ester) and poly(N-vinyl-2-pyrrolidone) blends: salicylic acid-releasing blends with hydrogel-like properties that reduce inflammation.

Macromolecular bioscience (2014-10-22)

Michelle A Ouimet, Renata Fogaça, Sabrina S Snyder, Sameer Sathaye, Luiz H Catalani, Darrin J Pochan, Kathryn E Uhrich

ABSTRACT

Polymers such as poly(N-vinyl-2-pyrrolidone) (PVP) have been used to prepare hydrogels for wound dressing applications but are not inherently bioactive. For enhanced healing, PVP was blended with salicylic acid-based poly(anhydride-esters) (SAPAE) and shown to exhibit hydrogel properties upon swelling. In vitro release studies demonstrated that the chemically incorporated drug (SA) was released from the polymer blends over 3-4 d in contrast to 3 h, and that blends of higher PVP content displayed greater swelling values and faster SA release. The polymer blends significantly the inflammatory cytokine, TNF-α, in vitro without negative effects.

MATERIALS

Product Number

Brand

Product Description

Supelco

Tetrahydrofuran, Selectophore^™, ≥99.5%

Supelco

Chloroform, analytical standard

Supelco

Chloroform, suitable for HPLC, ≥99.8%, contains 0.5-1.0% ethanol as stabilizer

Sigma-Aldrich

Tetrahydrofuran, anhydrous, contains 250 ppm BHT as inhibitor, ≥99.9%

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Chloroform, ACS reagent, ≥99.8%, contains 0.5-1.0% ethanol as stabilizer

Sigma-Aldrich

Chloroform, anhydrous, contains amylenes as stabilizer, ≥99%

Sigma-Aldrich

Tetrahydrofuran, anhydrous, ≥99.9%, inhibitor-free

Sigma-Aldrich

Chloroform, ACS reagent, ≥99.8%, contains amylenes as stabilizer

Sigma-Aldrich

Salicylic acid, ACS reagent, ≥99.0%

Sigma-Aldrich

Triethylamine, ≥99.5%

Sigma-Aldrich

Chloroform, anhydrous, ≥99%, contains 0.5-1.0% ethanol as stabilizer

Sigma-Aldrich

Salicylic acid, ≥99%, FG

Supelco

Tetrahydrofuran, analytical standard

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Triethylamine, for amino acid analysis, ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, BioUltra, ≥99.5% (GC)

Supelco

Dimethyl sulfoxide, analytical standard

Sigma-Aldrich

Salicylic acid, puriss. p.a., ≥99.0% (T)

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Salicylic acid, meets analytical specification of Ph. Eur., BP, USP, 99.5-100.5% (calc. to the dried substance)

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Salicylic acid, ReagentPlus^®, ≥99%

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Dimethyl sulfoxide, for molecular biology

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Dimethyl sulfoxide, PCR Reagent

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Dimethyl sulfoxide, ≥99.5% (GC), suitable for plant cell culture

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Dimethyl sulfoxide, Hybri-Max^™, sterile-filtered, BioReagent, suitable for hybridoma, ≥99.7%

Sigma-Aldrich

Salicylic acid, BioXtra, ≥99.0%

Sigma-Aldrich

Triethylamine, puriss. p.a., ≥99.5% (GC)

Sigma-Aldrich

Dimethyl sulfoxide, BioUltra, for molecular biology, ≥99.5% (GC)

Sigma-Aldrich

Triethylamine, ≥99.5%