SRP8027

CD24 (mouse): FC (human)

recombinant, expressed in HEK 293 cells, >90% (SDS-PAGE)

• Synonym(s): M1/69-J11D heat stable antigen, NaMN adenylyltransferase 1, Nectadrin, X62 Heat stable antigen (HSA)
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: mouse
• recombinant: expressed in HEK 293 cells
• Assay: >90% (SDS-PAGE)
• form: lyophilized
• mol wt: ~50 kDa by SDS-PAGE
• packaging: pkg of 50 μg
• impurities: <0.06 EU/μg endotoxin, tested
• UniProt accession no.: P24807
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: mouse ... CD24(100133941)

Description

General description

CD24 is a highly glycosylated protein expressed as glycosyl-phosphatidyl-inositol (GPI) anchored molecule. Widely expressed, mainly on T cells, B cells and is upregulated in numerous types of cancers. It has costimulatory activity for antigen specific T cell responses. Polymorphisms of human CD24 are associated with several autoimmune diseases. Recently a new role as negative regulator of the immune response has been reported. CD24-deficient mice are more sensitive to inflammatory responses. CD24 together with the membrane protein SIGLEC interacts with danger-associated molecular patterns (DAMPs), such as HMGB1, HSP90 or HSP70. CD24/SIGLEC complex may differentially regulate the host response to DAMPs and PAMPs (pathogen-associated molecular patterns).

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 50 μL deionized water.

Other Notes

Mouse CD24 (aa 27-52) is fused at the C-terminus to the Fc portion of human IgG1.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable