I8273

Anti-Interleukin-2 antibody produced in goat

IgG fraction of antiserum, lyophilized powder

• Synonym(s): Anti-IL-2
• MDL number: MFCD00675261
• UNSPSC Code: 51111800
• NACRES: NA.46

Properties

• biological source: goat
• Quality Level: 100
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: human
• technique(s): neutralization: suitable; western blot: 1 μg/mL
• UniProt accession no.: P60568
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... IL2(3558)

Description

General description

Interleukin-2 (IL-2) is a cytokine produced by activated T cells in response to antigen stimulation. IL-2 is important for proliferation of lymphocytes, natural killer cells and macrophages and in the differentiation of CD4⁺ cells into Th1 and Th2 effector cells. The effects of IL-2 are mediated by the signalling activated by its binding to IL-2 receptor (IL-2 R). IL-2 activates key signalling pathways such as MAPK, JAK/STAT as well as PI3K/Akt. Activation of these pathways modulates production of inflammatory cytokines, survival and progression through cell cycle
Monoclonal Anti-Interleukin-2 recognizes human Interleukin-2. It also neutralizes recombinant, mouse IL-2, but requires 30-50 times the antibody concentration required to neutralize human IL-2.

Specificity

The antibody neutralizes the biological activity of recombinant human IL-2.

Immunogen

recombinant human interleukin-2 expressed in Escherichia coli.

Application

Anti-interleukin-2 antibody is suitable for IL-2 neutralization assays.

Physical form

Lyophilized from a 0.2 μm filtered solution of phosphate buffered saline containing carbohydrates.

Preparation Note

Purified using protein G.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves