61327

Lactoferrin from human milk

iron-saturated, ≥85% (GE)

• CAS Number: 936541-36-5
• MDL number: MFCD00164307
• UNSPSC Code: 12352202
• NACRES: NA.61

Properties

• biological source: human milk
• Assay: ≥85% (GE)
• form: solid
• quality: iron-saturated
• mol wt: 82.4 kDa
• concentration: ≥0.15 % (w/w) Fe
• solubility: 0.05 M NaCl: 1 mg/mL, clear to faintly turbid, faintly red to brown
• UniProt accession no.: P02788
• storage temp.: 2-8°C
• InChI: 1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44-28(17(3)4)35(55)56/h7-11,16-19,21-23,27-28H,12-15,36H2,1-6H3,(H2,37,45)(H,38,49)(H,39,51)(H,40,54)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H,47,48)(H,55,56)/t18-,19-,21-,22-,23-,27-,28-/m0/s1
• InChI key: QCBUWCQOKPLTDZ-PKRULZLPSA-N
• Gene Information: human ... LTF(4057)

Description

Application

Lactoferrin was used for development of lactoferrin immunosensor.

Biochem/physiol Actions

Lactoferrin is an iron binding protein. It is structurally similar to transferrin, the plasma iron transport protein; but lactoferrin has a much higher affinity for iron (250 fold). It is very abundant in colostrum and small amounts can also be found in tears, saliva, mucous secretions and in the secondary granules of neutrophils. It is made by mucosal epithelium and neutrophils and is released by these cells in response to inflammatory stimuli. Bacterial growth is inhibited by its ability to sequester iron and also permeabilize bacterial cell walls by binding to lipopolysaccharides through its N-terminus. Lactoferrin can inhibit viral infection by binding tightly to the viral envelope protein. This prevents cell-virus fusion by blocking the binding domain. Lactoferrin appears to activate host defense systems in part by stimulating the release of interleukin-8, a neutrophil activator. It may also be involved in antibody and interleukin synthesis, lymphocyte proliferation and complement activation.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves