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870716P

Avanti

16:0 Coenzyme A

Avanti Research™ - A Croda Brand 870716P, powder

Synonym(s):

palmitoyl Coenzyme A (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C37H75N10O17P3S
CAS Number:
799812-86-5
Molecular Weight:
1057.03
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 10 mg (870716P-10mg)
pkg of 1 × 25 mg (870716P-25mg)
pkg of 1 × 5 mg (870716P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 870716P

application(s)

lipidomics

lipid type

coenzymes

shipped in

dry ice

storage temp.

−20°C

SMILES string

O[C@@](C(NCCC(NCCSC(CCCCCCCCCCCCCCC)=O)=O)=O)(C(C)(COP([O-])(OP([O-])(OC[C@H]([C@H]1OP([O-])(O)=O)O[C@H]([C@@H]1O)N2C3=C(C(N)=NC=N3)N=C2)=O)=O)C)[H].[NH4+].[NH4+].[NH4+]

InChI

1S/C37H66N7O17P3S.3H3N/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44;;;/h24-26,30-32,36,47-48H,4-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52);3*1H3/t26-,30?,31+,32+,36-;;;/m1.../s1

InChI key

VJXJWGKNGIGUQX-AUCFWDBISA-N

General description

16:0 Coenzyme A, also called as palmitoyl coenzyme A, is a most abundant acyl-CoA and the product of the first round of β-oxidation. It serves as a substrate for palmitoylation, a process in which a protein acyltransferase transfers the palmitoyl group to a free thiol on target proteins.

Application

16:0 Coenzyme A has been used as a:
  • standard in mass spectrometry for qualitative analysis of palmitoyl acyl-CoA in mycobacterium cells
  • constituent of the binding buffer in protein in vitro binding assay
  • substrate in serine palmitoyltransferase assay

Packaging

5 mL Amber Glass Screw Cap Vial (870716P-10mg)
5 mL Amber Glass Screw Cap Vial (870716P-25mg)
5 mL Amber Glass Screw Cap Vial (870716P-5mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cheryl Budde et al.
Methods (San Diego, Calif.), 40(2), 143-150 (2006-10-03)
Palmitoylation enhances membrane association and plays a role in the subcellular trafficking and signaling function of proteins. Unlike other forms of protein lipidation, such as prenylation and myristoylation, palmitoylation is reversible and can therefore play a regulatory role. Enzyme activities
Matías Cabruja et al.
Applied microbiology and biotechnology, 100(16), 7239-7248 (2016-06-09)
Acyl-CoAs are crucial compounds involved in essential metabolic pathways such as the Krebs cycle and lipid, carbohydrate, and amino acid metabolisms, and they are also key signal molecules involved in the transcriptional regulation of lipid biosynthesis in many organisms. In
Oshrit Ben-David et al.
The Journal of biological chemistry, 286(34), 30022-30033 (2011-06-28)
Sphingolipids (SLs) act as signaling molecules and as structural components in both neuronal cells and myelin. We now characterize the biochemical, histological, and behavioral abnormalities in the brain of a mouse lacking very long acyl (C22-C24) chain SLs. This mouse
Anke Penno et al.
The Journal of biological chemistry, 285(15), 11178-11187 (2010-01-26)
HSAN1 is an inherited neuropathy found to be associated with several missense mutations in the SPTLC1 subunit of serine palmitoyltransferase (SPT). SPT catalyzes the condensation of serine and palmitoyl-CoA, the initial step in the de novo synthesis of sphingolipids. Here
Taras Y Nazarko et al.
The Journal of cell biology, 204(4), 541-557 (2014-02-19)
Autophagy is a membrane trafficking pathway that sequesters proteins and organelles into autophagosomes. The selectivity of this pathway is determined by autophagy receptors, such as the Pichia pastoris autophagy-related protein 30 (Atg30), which controls the selective autophagy of peroxisomes (pexophagy)
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