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  • cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein.

cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein.

FEBS letters (1995-01-03)
H Nishimura, I Kakizaki, T Muta, N Sasaki, P X Pu, T Yamashita, S Nagasawa
ABSTRACT

PK-120 is a substrate for plasma kallikrein (PK), recently purified from human plasma. Here we have established the cDNA sequence for human PK-120 mRNA. The deduced amino sequence of PK-120 revealed that it consists of 902 amino acid residues with a calculated mass of 116,423 Da. The putative cleavage sites by PK have been proposed, suggesting that PK-120 may be a precursor of a bioactive peptide. Most interestingly, PK-120 showed significant sequence identities to heavy chains (HCs) of the inter-alpha-trypsin inhibitor (ITI) superfamily.