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Cobalt: its role in health and disease.

Cobalt: its role in health and disease.

Metal ions in life sciences (2014-01-29)

Kazuhiro Yamada

ABSTRACT

The primarily function of cobalt in humans is based on its role in cobalamin (Cbl, vitamin B12). Therefore, this chapter will focus on the physiological roles of Cbl and the importance of cobalt in human health. Cbl acts as the cofactor for two enzymes, i.e., methylmalonyl-CoA mutase and methionine synthase, in humans. Both enzymes are important for health. In addition, unlike other water-soluble vitamins, there is a unique absorption, delivery, and activation system for Cbl in mammals. Therefore, this chapter will also review the literature on the Cbl transporting system, which is crucial for Cbl function.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, 99.95% trace metals basis

Sigma-Aldrich

Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

Sigma-Aldrich

Cobalt, rod, diam. 5.0 mm, 99.95% trace metals basis

Sigma-Aldrich

Cobalt, powder, <150 μm, ≥99.9% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 1.0 mm, 99.95% trace metals basis

Sigma-Aldrich

Cobalt, foil, thickness 0.1 mm, ≥99.99%

Sigma-Aldrich

Cobalt, Carbon coated magnetic, nanopowder, <50 nm particle size (TEM), ≥99%

Sigma-Aldrich

Cobalt, granular, 99.99% trace metals basis

Sigma-Aldrich

Cobalt, pieces, 99.5% trace metals basis

Sigma-Aldrich

Cobalt, wire, diam. 1.0 mm, 99.995% trace metals basis

Cobalt, foil, 8mm disks, thickness 0.02mm, 99.9%

Cobalt, foil, 4mm disks, thickness 0.25mm, as rolled, 99.9%

Cobalt, foil, 25mm disks, thickness 0.25mm, as rolled, 99.99+%

Cobalt, wire reel, 0.2m, diameter 0.05mm, hard, 99.9%

Cobalt, wire reel, 1m, diameter 0.5mm, hard, 99.99+%

Cobalt, wire reel, 0.2m, diameter 0.25mm, hard, 99.99+%

Cobalt, wire reel, 0.5m, diameter 0.05mm, hard, 99.9%

Cobalt, wire reel, 1m, diameter 0.05mm, hard, 99.9%

Cobalt, wire reel, 0.2m, diameter 0.5mm, hard, 99.99+%

Cobalt, wire reel, 0.5m, diameter 0.1mm, hard, 99.99+%

Cobalt, wire reel, 1m, diameter 0.125mm, hard, 99.99+%

Cobalt, wire reel, 2m, diameter 0.125mm, hard, 99.99+%

Cobalt, wire reel, 0.2m, diameter 1.0mm, hard, 99.99+%

Cobalt, wire reel, 0.5m, diameter 0.25mm, hard, 99.99+%

Cobalt, wire reel, 2m, diameter 0.1mm, hard, 99.99+%

Cobalt, wire reel, 0.2m, diameter 0.125mm, hard, 99.99+%

Cobalt, wire reel, 0.2m, diameter 2.0mm, hard, 99.99+%

Cobalt, wire reel, 0.5m, diameter 0.5mm, hard, 99.99+%

Cobalt, wire reel, 2m, diameter 0.25mm, hard, 99.99+%

Cobalt, wire reel, 0.2m, diameter 0.1mm, hard, 99.99+%