- pH-dependent conformational switching in 2,6-benzamidodiphenylacetylenes.
pH-dependent conformational switching in 2,6-benzamidodiphenylacetylenes.
Angewandte Chemie (International ed. in English) (2011-12-17)
Ian M Jones, Hannah Lingard, Andrew D Hamilton
PMID22173825
ABSTRACT
The conformational equilibrium of a pH-dependent switch based on an intramolecularly H-bonded diphenylacetylene can be predictably biased by using electron-donating or -withdrawing groups. Furthermore, protonation of the electron-donating dimethylamino group converts it into an electron-withdrawing dimethylammonium cation with a concomitant switch in conformation.
MATERIALS