SRP6090
AKR1B10 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
AKR1B11, ALDRLn, ARL-1, Aldo-keto reductase family member B10, HIS
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About This Item
UNSPSC Code:
12352204
NACRES:
NA.32
biological source
human
recombinant
expressed in E. coli
Assay
≥90% (SDS-PAGE)
form
liquid
mol wt
36 kDa
packaging
pkg of 100 μg
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AKR1B10(57016)
General description
AKR1B10 is a monomeric protein that efficiently catalyzes the reduction of aromatic and aliphatic aldehydes and ketones. AKR1B10 is ubiquitously expressed in many human tissues but is highly expressed in small intestine, colon and adrenal gland. This protein is pathogenically involved in diabetic complications. It has been reported that AKR1B10 is overexpressed in human tumors, such as liver, breast, and lung cancer, and may play a critical role in the development and progression of cancer.
Physical form
1 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol.
Preparation Note
Centrifuge the vial prior to opening.
Other Notes
MATFVELSTK AKMPIVGLGT WKSPLGKVKE AVKVAIDAGY RHIDCAYVYQ NEHEVGEAIQ EKIQEKAVKR EDLFIVSKLW PTFFERPLVR KAFEKTLKDL KLSYLDVYLI HWPQGFKSGD DLFPKDDKGN AIGGKATFLD AWEAMEELVD EGLVKALGVS NFSHFQIEKL LNKPGLKYKP VTNQVECHPY LTQEKLIQYC HSKGITVTAY SPLGSPDRPW AKPEDPSLLE DPKIKEIAAK HKKTAAQVLI RFHIQRNVIV IPKSVTPARI VENIQVFDFK LSDEEMATIL SFNRNWRACN VLQSSHLEDY PFDAEY
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Yihao Tian et al.
PloS one, 6(2), e17017-e17017 (2011-03-03)
Oncogenes and tumor suppressors work in concert to regulate cell growth or death, which is a pair of antagonist factors for regulation of tumorigenesis. Here we show promoter characteristic of tumor suppressor RASSF1A, which revealed a p53 binding site in
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