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SML3734

Sigma-Aldrich

AO-159

≥98% (HPLC)

Synonym(s):

2,3,6,7-Tetramethyl 9-(4-methoxyphenyl)-1,4,8-trithiaspiro[4.5]deca-2,6,9-triene-2,3,6,7-tetracarboxylate, 9-(4-Methoxyphenyl)-1,4,8-trithiaspiro[4.5]deca-2,6,9-triene-2,3,6,7-tetracarboxylic acid 2,3,6,7-tetramethyl ester

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About This Item

Empirical Formula (Hill Notation):
C22H20O9S3
CAS Number:
354792-76-0
Molecular Weight:
524.58
MDL number:
MFCD02182957
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

AO-159 is a cell penetrant and potent pan-HMT (pan- Histone Methyltransferase) inhibitor that effectively inhibit the enzymatic activity of both G9a and Suv39H1 enzymes. AO-159 potently reduces the levels of H3K9me1, H3K9me2, and H3K9me3 in COS7 cells. In inhibits the five histone H3K9 methylating enzymes Suv39H1, Suv39H2, SETDB1, G9a, and GLP at low micromolar concentrations.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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