SAB5200022

Monoclonal Anti-CACNA1D antibody produced in mouse

clone S48A-9, 1 mg/mL, purified immunoglobulin

• Synonym(s): Anti-CACH3, Anti-CACN4, Anti-CACNA 1D, Anti-CACNL1A2, Anti-Cav1.3, S48A-9, Anti-oltage dependent L type calcium channel subunit alpha 1D
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: mouse
• conjugate: unconjugated
• antibody form: purified immunoglobulin
• antibody product type: primary antibodies
• clone: S48A-9, monoclonal
• form: buffered aqueous glycerol solution
• mol wt: antigen predicted mol wt 250 kDa
• species reactivity: human, rat, mouse
• concentration: 1 mg/mL
• technique(s): immunocytochemistry: suitable; immunoprecipitation (IP): suitable; western blot: suitable
• isotype: IgG2aκ
• NCBI accession no.: NP_058994.1
• UniProt accession no.: Q01668
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: rat ... Cacna1d(29716)

Description

General description

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is expressed in many tissues and possesses six transmembrane segments, along with a loop lining the pore of the channel. The gene encoding CACNA1D is localized on human chromosome 3p14.3.

Specificity

Detects ~250 kDa. No cross-reactivity against Cav1.2

Immunogen

Fusion protein amino acids 859-875 of rat Cav1.3, Accession Number P27732

Application

Monoclonal Anti-CACNA1D antibody produced in mouse has been used in immunocytochemistry.

Biochem/physiol Actions

Calcium channel, L type α-1 polypeptide isoform 2 (CACNA1D) is crucial for the functioning of the brain and in hearing. It gets activated at a fast rate and withstands high inward Ca²⁺ currents even at threshold voltages. CACNA1D aids in dendritic signals linked to mitochondrial stress in the brain and is important for estrogen-stimulated Ca²⁺ influx. Studies have shown that in atrial myocytes, the C terminus of the channel translocates to the nucleus and regulates Ca²⁺-activated K⁺ channels. CACNA1D was shown to be upregulated in endometrial cancer and its knockdown showed a reduction in cell proliferation in vitro. Mutations in the gene encoding it has been associated with aldosterone-producing adenomas (APAs), where it leads to the formation of small adenomas.

Features and Benefits

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Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable