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Key Documents

SAB2501867

Sigma-Aldrich

Anti-NPR3 (C-terminal) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Synonym(s):

ANPRC, GUCY2B, NPRC, natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

goat

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, canine, pig, rat, bovine

technique(s)

immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

UniProt accession no.

P17342

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... NPR3(4883)

General description

Natriuretic peptide receptor 3 (NPR3) is a natriuretic peptide receptor. It is expressed in endothelial cells, vessels, endocrine glands, lungs and kidneys. The gene encoding NPR3 is localized on human chromosome 5p14-p13. The protein consists of a 450-amino acid extracellular ligand-binding domain, a transmembrane region and a cytoplasmic tail.

Immunogen

Peptide with sequence C-HRELREDSIRSHFS, from the C-terminal region of the protein sequence according toNP_000899.1

Application

Anti-NPR3 (C-terminal) antibody produced in goat has been used in Western blotting.

Biochem/physiol Actions

Natriuretic peptide receptor 3 (NPR3) has a role in the clearance of natriuretic peptides and modulates their plasma levels. It is associated with essential hypertension. NPR3 may be involved in signaling pathways and is associated with inhibitory G protein.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Deborah Carper et al.
Cell reports, 32(8), 108075-108075 (2020-08-28)
Atrial natriuretic peptide (ANP) is a cardiac hormone controlling blood volume and pressure in mammals. It is still unclear whether ANP controls cold-induced thermogenesis in vivo. Here, we show that acute cold exposure induces cardiac ANP secretion in mice and humans.
Association of NPRA and NPRC gene variants and hypertension in Mongolian population.
Chang PY
Genetics and molecular research : GMR (2015)
Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation.
Pereira NL
Circulation. Cardiovascular Genetics (2013)
Attenuated atrial natriuretic peptide-mediated
lipolysis in subcutaneous adipocytes of obese
type 2 diabetic men
Kenneth Verboven
Clinical Science (2016)
NPR-C gene polymorphism is associated with increased susceptibility to coronary artery disease in Chinese Han population: a multicenter study.
Hu Q
Oncotarget (2016)

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